Van de Ven Double Halts Everton's Run at New Home Ground
The Dutch defender became the first backline player to score two goals in a English top-flight game for Spurs since Jan Vertonghen in March 2013.
At a glance
The Spurs defender heads into the net twice in opening period
Everton's Jake O'Brien has goal disallowed after video check
Senegalese midfielder nets final goal in 89th minute
This loss is Everton's initial at Hill Dickinson Stadium
The Tottenham defender found the net on two occasions as Spurs extended their winning streak in away games in the Premier League and handed the Toffees their first defeat at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having left Goodison Park behind after 133 years at the conclusion of the previous campaign.
But Spurs captain the Dutchman struck on two occasions from corners in the opening 45 minutes to place their strong form at jeopardy, and they were failed to turn it around before the midfielder - set up by ex-Everton forward the Brazilian - headed home a final goal to seal the victory.
Jake O'Brien believed he had levelled the scores five minutes after Van de Ven's opener, glancing a powerful header past Guglielmo Vicario from an Everton corner.
Beto, meanwhile, missed a number of chances, while the Italian goalkeeper made a succession of fine saves to ensure Tottenham went five away games without defeat in the Premier League.
But the VAR stepped in, advising Craig Pawson to check the goal on the pitchside monitor and the official ruled that Jack Grealish and the attacker were in offside positions and had impeded with the Tottenham goalkeeper.
This victory elevates the manager's side up to third in the division, five points off local foes and table-toppers the Gunners.
Everton stay 14th and are six points clear of the relegation zone.
Tottenham analysis: Van de Ven excels in duties at both ends of pitch
Following a drab midweek performance in the European competition against the French side, where they managed a only attempts on target, the manager opted for Randal Kolo Muani in attack instead of former Toffees player the Brazilian.
The summer signing was failed to influence the game before being substituted for Richarlison after 60 minutes on the pitch, but it turns out he proved unnecessary in the final outcome.
Defender the Dutchman converted into an attacking force to be feared.
Tottenham's opening strike came from a well-worked corner routine, with the midfielder directing the ball toward the face of goal for an unmarked Van de Ven to score.
And Ven de Ven - stepping up as skipper in the Argentine's unavailability - notched his second in first-half stoppage time as he outjumped the England keeper to nod in.
Van de Ven was just as outstanding in defence, partnering effectively with Kevin Danso as the pair dealt excellently with the numerous deliveries thrown their way by Everton.
Everton analysis: Toffees lacking finishing touch
Everton's new home had been a happy hunting ground, but it appears the novelty may have worn off slightly and supporters headed to the gates after Sarr's final goal for Spurs.
The break in Everton's winning streak at home will not be a major worry for the manager, but their striker situation are.
Beto and Thierno Barry - the Toffees' two recognised centre-forwards - had netted only one league goal between them before Sunday's match.
And they were failed to contribute to that poor tally on a damp and dreary night on Merseyside.
The striker's form was summed up when he chose to overhead kick a clear chance from near the goal, even with having room and opportunity to reposition for a simpler shot that would have challenged Vicario.
Barry, as well, failed to influence the game after coming on for the starter in the 65th minute.
It was not for a shortage of chance. The majority of the home side's offensive moves came through the winger and Ndiaye, who tirelessly delivered dangerous balls into the Tottenham box.
What next for these two sides?
The Toffees: Moyes' men head to the Stadium of Light in the Premier League on Monday, 3 November at 20:00 GMT.
Tottenham: The London club travel to Newcastle's ground on late October for their next round League Cup match against the Magpies.